CHAT was used to identify and compare contextual and degree-based hubs in this network. In a case study, we use CHAT to construct a network of genes that are differentially expressed in Dengue fever, a viral infection.
genes or proteins that are differentially expressed) than expected by chance. Here, we report a Cytoscape app, the Contextual Hub Analysis Tool (CHAT), which enables users to easily construct and visualize a network of interactions from a gene or protein list of interest, integrate contextual information, such as gene expression or mass spectrometry data, and identify hub nodes that are more highly connected to contextual nodes (e.g. The relative importance of a hub node, however, can change depending on the biological context. Highly connected nodes (hubs) in biological networks are topologically important to the structure of the network and have also been shown to be preferentially associated with a range of phenotypes of interest.
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